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KMID : 0356419950130010001
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Journal of Korean Andrology
1995 Volume.13 No. 1 p.1 ~ p.6
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Localization of Nur77 mRNA in Mouse Testes by in Situ Hybridization
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Abstract
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By identifying the mRNA products of stage-and cell-specific gene expression directly in histologic specimens, in situ hybridization provides a powerful tool to demonstrate the cellular mechanisms regulating spermatogenesis. Nur77 is a member of
the
growth factor-inducibel "immediate early" genes and is highly homologous to sequences of members of the steroid/thyroid hormone receptor gene superfamily. We investigated a putative role for nur77 during spermatogenesis by probing for its
expression
using in situ hybridization in mouse testes. Expression of the nur77 gene was restricted to the round spermatids in stages IV through VI. The identificantion of nur77 as a discretely, temporally expressed gene during germ cell differentiation
indicates
its pivotal function in spermatogenesis. Its abnormal expression may be important in defining a specific cause of unexplained testicular failure in some patients.
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KEYWORD
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